Study News & Selected Publications

Recent News

Recently the MINDDS II study was announced at the ANESTHESIOLOGY 2024 Annual Meeting from the American Society of Anesthesiologists in October 2024. This presentation was part of a panel on ‘NIH-Funded Clinical Trials in Anesthesiology: Current Studies, Networks and Innovations.”

During this panel, Dr. Susana Vacas, one of the MINDDS II Co-Investigators from Massachusetts General Hospital provided an update on the study, emphasizing the teamwork and communication that has made MINDDS II a success to date.

“This study and its people are a collection of intellectual talent which will lead us to a real tangible solution that clinicians will be able to offer their patients.”
— Susana Vacas, MD PhD

Selected Publications

eClinicalMedicine

Nighttime dexmedetomidine for delirium prevention in non-mechanically ventilated patients after cardiac surgery (MINDDS): A single-centre, parallel-arm, randomised, placebo-controlled superiority trial

Association Between Postoperative Delirium and Long-Term Subjective Cognitive Decline in Older Patients Undergoing Cardiac Surgery: A Secondary Analysis of the Minimizing Intensive Care Unit Neurological Dysfunction with Dexmedetomidine-Induced Sleep Trial

Journal of Cardiothoracic and Vascular Anesthesia

Annals of Surgery

Preoperative Plasma Tau-PT217 and Tau-PT181 Are Associated With Postoperative Delirium

Anesthesiology

Sex Differences in the Incidence of Postoperative Delirium after Cardiac Surgery: A Pooled Analyses of Clinical Trials

British Journal of Anaesthesia

Tau as a serum biomarker of delirium after major cardiac surgery: a single centre case-control study

Frontiers in Aging Neuroscience

Serum Proteomics of Older Patients Undergoing Major Cardiac Surgery: Identification of Biomarkers Associated With Postoperative Delirium

Brain Communications

Cognitive function mediates the relationship between age and anaesthesia-induced oscillatory-specific alpha power

Journal of Cardiothoracic and Vascular Anesthesia

Preliminary Study of Serum Biomarkers Associated With Delirium After Major Cardiac Surgery